Fumonisin- and AAL-Toxin-lnduced Disruption of Sphingolipid Metabolism with Accumulation
نویسندگان
چکیده
Southern Weed Science Laboratory, United States Department of Agriculture/Agricultural Research Service, Stoneville, Mississippi 38776 (H.K.A., S.O.D.); Ube Industries, Ltd., Ube City, Japan (T.T.); Toxicology and Mycotoxins Research Unit, United States Department of Agriculture/Agricultural Research Service, P.O. Box 5677, Athens, Georgia 30604-5677 (J.K.P., E.M.W., R.T.R.); Department of Chemistry, Agnes Scott College, Atlanta, Georgia (L.H., A.E.S.); and Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 (E.W., A.H.M.)
منابع مشابه
Pii: S0031-9422(97)00781-4
Abstraet--AAL-toxins and fumonisin B~ are phytotoxic to susceptible plants by inhibiting the enzyme ceramide synthase. Australifungin, which is structurally unrelated to these toxins, inhibits the same enzyme in the sphingolipid biosynthesis pathway of animals. In duckweed (Lemna pausicostata)cultures, 5 ~M australifungin caused accumulation of the sphingolipid precursors, phytospingosine and s...
متن کاملEvidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins.
Fumonisins are inhibitors of the biosynthesis of sphingosine and more complex sphingolipids. In eucaryotic cells, fumonisin inhibition of sphingolipid biosynthesis is a result of inhibition of the enzyme ceramide synthase. Large increase in free sphinganine concentration in plant and animal cells are observed within a few hours after exposure to fumonisins and/or Alternaria toxins (AAL-toxins)....
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The nectrotrophic fungus Alternaria alternata f.sp. lycopersici infects tomato plants of the genotype asc/asc by utilizing a host-selective toxin, AAL-toxin, that kills the host cells by inducing programmed cell death. Asc-1 is homologous to genes found in most eukaryotes from yeast to humans, suggesting a conserved function. A yeast strain with deletions in the homologous genes LAG1 and LAC1 w...
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The fungus Fusarium verticillioides is a pathogen of many plants and produces fumonisins. In addition to their well-studied animal toxicoses, these toxins contribute to the development of maize seedling disease in susceptible maize varieties. Fumonisin disruption of sphingolipid biosynthesis occurs during pathogenesis. An extraction method was developed for the simultaneous analysis of fumonisi...
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Ultrastructural effects of AAL-toxin TA from Alternaria alternata on black nightshade (Solanum, nigrum L.) leaf discs and correlation with biochemical measures of toxicity. In black nightshade (Solanum nigrum L.) leaf discs floating in solutions of AAL-toxin TA (0.01-200 microM) under continuous light at 25 degrees C, electrolyte leakage, chlorophyll loss, autolysis, and photobleaching were obs...
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